20th International Workshop on Kaposi ́s
Sarcoma Herpes Virus (KSHV)
and Related Agents

25–28 July 2017 • Berlin, Germany

20th International Workshop on Kaposi ́s
Sarcoma Herpes Virus (KSHV)
and Related Agents

25–28 July 2017 • Berlin, Germany

SCIENTIFIC PROGRAMME

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Scientific programme

Please click here to open the Programme and Abstract book of KSHV 2017. (The password will be sent to all registered participants)

Please find the scientific programme below.

15:00 – 17:15 Registration
17:15 – 19:00 Session 1: Clinical Applications and Epidemiology
Chairs Denise Whitby (Frederick, MD/USA), Rob Newton (Entebbe/UG)
17:15 High throughput screening identifies cytarabine as an effective therapeutic agent to treat primary effusion lymphoma by targetinmg KSHV latent and lytic replication
Marion Gruffaz, Karthik  Vasan, Shou Jiang Gao* (Los Angeles, CA/USA)
17:30  Determinants of KSHV seropositivity and viral load detection in blood and saliva in a large KS case control study in Cameroon
Vickie Marshall*, Nazzarena Labo, Brendon McCann, Nathan Clemens, Wendell Miley, ELiza Davis (Frederick, MD/USA), Kristen Stolka (Research Triangle Park, NC/USA), Paul  N'Dom (Yaounde, Cameroon), Denise Whitby (Frederick, MD/USA)
17:45  Plasma immunoglobulin E (IgE) levels are associated with Kaposi's Sarcoma in HIV-infected African adults
Arturo Barbachano-Guerreri (Syracuse, NY/USA), Helen Byakwaga (Mbarara, Uganda), Dongliang Wang (Syracuse, NY/USA), Miriam Laker-Oketta (Kampala, Uganda), Conrad Muzoora (Mbarara, Uganda), Peter Hunt (San Francisco, CA/USA), Shelia Dollard (Atlanta, GA/United States), Jeffrey Martin (San Francisco, CA/USA)
, Christine King* (Syracuse, NY/USA)
18:00  Antiretroviral therapy reduces human herpesvirus-8 replication among Ugandan adults with HIV infection
Phipps Warren*, Elizabeth Krantz (Seattle, WA/USA), Peter Mooka, Mary Kalinaki (Kampala/Uganda), Katie Maggard, Jackson Orem (Seattle, WA/USA), Corey Casper (Kampala/Uganda) (Seattle, WA/USA)
18:15  Whole genome sequence analysis of KSHV from clinical samples
Vickie Marshall*, Elena Cornejo Castro, Nazzarena Labo, Taina Immonen, Priyanka Vengurlekar (Frederick, MD/USA), Kathleen Wyvill Karen  Aleman, Kathryn Lurain, Mark Pollizzotto (Bethesda, MD/USA), Brandon Keele (Frederick, MD/USA), Robert Yarchoan, Thomas Uldrick (Bethesda, MD/USA), Denise Whitby (Frederick, MD/USA)
18:30 Patient biopsies from the multinational Kaposi"s Sarcoma Trial A5264_AMC062 show broad variability in the percentage of LANA+ cells and only rare lytic reactivation
Scott Ely*, Andrea Gardner (New York, NY/USA), Triin Umbleja (Boston, MA/USA), Aggrey Bukuru (Kampala/Uganda), Jeffrey Martin (San Francisco, CA/USA), Thomas Campbell (Denver, CO/USA) Mina Hosseinipour (Lilongwe/ Malawi), Susan Krown (New York, NY/USA), Catherine Godfrey (Bethesda, MD/USA), Robert Coombs (Seattle, WA/USA), Ethel Cesarman (New York, NY/USA)
18:45  Gene expression profiling of Kaposi's Sarcoma Lesions
For Yue Tso (Lincoln, NE/USA), Andrew Kossenkov (Philadelphia, PA/USA) Owen Ngalamika (Lusaka/Zambia), Salum Lidenge (Lincoln, NE/USA), John Ngowi Richards (Dar es Salaam/Tanzania), Eun Hee Kwong (Lincoln, NE/USA), Julius Mwaiselage (Dar es Salaam/Tanzania), Paul  Liberman (Philadelphia, PA/USA), John West, Charles Wood* (Lincoln, NE/USA)
19:00 – 21:00 Welcome Reception
08:30 – 10:30 Session 2: Virus-Host Interaction I
Chairs Dirk Dittmer (Chapel Hill, NC/USA), Melanie Brinkmann (Braunschweig/Germany)
08:30  Unique features of KSHV Infection in tonsil-derived stromal cells
Jennifer Totonchy* (Irvine, CA/USA; New York, NY/USA), Jessica Osborn, Ayana Morales, Ethel Cesarman (New York, NY/USA)
08:45  hIL-6 signalling controls maturation in KSHV-infected B lymphocytes
Jennifer Totonchy* (Irvine, CA/USA; New York, NY/USA), Jessica Osborn, Ethel Cesarman (New York, NY/USA)
09:00  KSHV vIL-6 induces class-switch recombination in B cells
Santas Rosario, Enrique Mesri*, Ramiro Verdun (Miami, FL/USA)
09:15  Genome-wide CRISPR screens identifies MCL1 as a critical player in the survival of KSHV-transformed primary effusion lymphoma cell lines
Mark Manzano*, Ajinkya Patil, Amir Behdad, Eva Gottwein (Chicago, IL/USA)
09:30  How Epstein-Barr virus likely contributes to primary effusion lymphomas?
Aurelia Faure*, Bill Sugden (Madison, WI/USA)
09:45  Kinome profiling of non-hodgkin lymphoma
Jason P. Wong*, Timothy J. Stuhlmiller, Louise C. Giffin, Carolina Lin, Rachele Bigi, Xiaodong Wang, Dirk Dittmer, Stephen V.  Frye, Gary L. Johnson, Blossom Damania (Chapel Hill, NC/USA)
10:00 Uncovering the interplay of Kaposi Sarcoma Herpesvirus with the host cell cycle as a way to limit virus spread and cancer progression
Endrit Elbasani*, Silvia Gramolelli, Giuseppe Balistreri, Tomasz Benedyk (Helsinki/Finland), Päivi Ojala (Helsinki/Finland; London/UK)
10:15 

Defining the role of PROX1 in KS pathogenesis and KSHV life cycle
Silvia Gramolelli*, Endit  Elbasani, Krista Ojala, Raquel Diaz Martinez, Elisa Kaivanto, Markus Vaha-Koskela (Helsinki/Finland), Janpin  Cheng (Lausanne/Switzerland), Ines Martinez-Corral (Uppsala/Sweden), Kari Alitalo (Helsinki/Finland), Taija Mäkinen (Uppsala/Sweden), Tatiana  Petrova (Lausanne/Switzerland), Päivi Ojala (Helsinki/Finland; London/UK)

10:30 – 11:00 Coffee break
11:00 – 12:45 Session 3: Latency
Chairs Ken Kaye (Boston, MA/USA), Armin Ensser (Erlangen/Germany)
11:00  The KSHV lana internal repeat elements are required for in vivo latecy in chimeric virus
Marta Pires de Miranda (Lisbon/Portugal), Franceline Juillard, Aline C. Habison, Chantal Beauchemin, Min Tan (Boston, MA/USA), Bruno Correia, Rajesh Ponnusamy (Oeiras/PT), Edward J. Usherwood (Lebanon, NH/US), Colin McVey (Oeiras/PT), Andre Seixas, J. Pedro Simas (Lisbon/Portugal), Kenneth Kaye* (Boston, MA/USA)
11:15  Role of Brd/BET proteins in mediating LANA chromatin association
Rishikesh Lotke*, Magdalena Weidner-Glunde (Hannover/Germany), Thomas Guenther (Hamburg/Germany), Jessica Rueckert (Hannover/Germany), Adam Grundhoff (Hamburg/Germany), Thomas Schulz (Hannover/Germany)
11:30  HHV-8 vFLIP is stabilized by MAVS on peroxisomes
Yong Bong Choi (Baltimore, MD/USA)
11:45  A novel role for a viral interferon regulatory factor during the establishment of KSHV latency
Sandra Koch* (Hannover/Germany; Braunschweig/Germany), Modester Damas (Hannover/Germany; Dar es Salaam/Tanzania), Elias Hage, Akshay Dhingra, Jessica Rückert (Hannover/Germany; Braunschweig/Germany), Antonio Gallo, Wolfram Brune (Hamburg/Germany), Thomas F Schulz (Hannover/Germany; Braunschweig/Germany)
12:00  New insights into KSHV latency establishment by comparative epigenomics and live cell imaging of viral DNA
Thomas Günther*, Uwe Tessmer (Hamburg/Germany), Shinji Ohno (Munich/ Germany), Lia Burkhardt (Hamburg/Germany), Heiko Adler (Munich/Germany), Adam Grundhoff (Hamburg/Germany)
12:15 Epstein-Barr virus increases cell proliferation and enhances Latency-Associated Nuclear Antigen expression in primary effusion lymphoma cell lines
Rachele Bigi*, Dirk Dittmer (Chapel Hill, NC/USA)
12:30  The KSHV episome-host chromatin synapse: Elucidation of nanoscale architecture
Margaret J. Grant, M. Mitchell Smith, Dean H. Kedes* (Charlottesville, VA/USA)
12:45 – 13:30 Lunch break
13:30 – 15:00 Session 4: Epigenetics & Gene Expression
Chairs Adam Grundhoff (Hamburg/Germany), Ronit Sarid (Ramat Gan/Israel)
13:30  Modulation of cellular CpG DNA methylation by Kaposi"s Sarcoma Associated Herpesvirus
Guy Journo, Carmel Tushinsky (Safed/Israel), David Diaz-Polak (Haifa/Israel), Yonatan Eran, Asia Shterngas, Milana Frenkel-Morgenstern (Safed/Israel), Reuven Bergman (Haifa/Israel), Meir Shamay* (Safed/Israel)
13:45

Viral and cellular N6-methyladenosine (m6A) epitranscriptomes in KSHV life cycle
Brandon Tan* (Los Angeles, CA/USA), Hui Liu (Xuzhou/China), Suzane Ramos Da Silva (Los Angeles, CA/USA), Lin Zhang (Xuzhou/China), Jia Meng (Suzhou/China), Xiaodong  Cui, Songyao Zhang (San Antonio, TX/USA), Hongfeng Yuan, Oceane Sorel (Los Angeles, CA/USA), Yufei Huang (San Antonio, TX/USA), Shou-Jiang Gao (Los Angeles, CA/USA)

14:00 Caspase-dependent RAD21-cleavage deregulates KSHV latency conformation and repression of lytic transcription in pleural effusion lymphoma cell lines
Alessandra De Leo, Horng-Shen Chen, Paul Liebermann* (Philadelphia, PA/USA)
14:15 Spatiotemporal gene regulation and KSHV replication
Mel Campbell, Christopher Chen, Yuanzhi Lyu, Kazushi Nakano, Chie Izumiya (Sacramento, CA/USA), Tadashi Watanabe (Kyoto/Japan), Yoshihiro Izumiya* (Sacramento, CA/USA)
14:30 To cut or not to cut: RNA target selection of the KSHV host-shut- off factor SOX
Carolin Vogt (Hannover/Germany), Marta Maria Gaglia (Boston, MA/USA), Aaron Mendez (Berkeley, CA/USA), Jens Bohne (Hannover/Germany), Britt A. Glaunsinger (Berkeley, CA/USA)
14:45  Kaposi"s sarcoma-associated herpesvirus (KSHV) ORF59 interacts with histones and targets PAN RNA to the viral genome for lytic gene expression
Poulomee Sarkar, Gregory Pari, Cyprian Rossetto* (Reno, NV/USA)
15:00 – 18:00 Excursions (optional)
19:00 – 21:00 Poster Session I
08:30 – 10:15 Session 5: Virus-Host Interaction II
Chairs Blossom Damania (Chapel Hill, NC/USA), Frank Neipel (Erlangen/Germany)
08:30  KSHV vIRF1 induces endothelial cell migration, invasion and angiogenesis by down-regulating miR-218-5p expression and activating CDCP1 signaling
Wan Li*, Qin Yan (Nanjing/China), Shou-Jiang Gao (Los Angeles, CA/USA), Chun Lu (Nanjing/China)
08:45  KSHV vIRF1 enhances Wnt11 transcription to promote KSHV lytic replication and oncogenesis
Chao Ma* (Shanghai/China), Ke Lan (Wuhan/China)
09:00 Rhesus macaque rhadinovirus disrupts promyelocytic leukemia nuclear bodies in a viral interferon regulatory factor dependent manner
Laura Springgay*, Bridget Robinson, Scott Wong (Beaverton, OR/USA)
09:15 Proteasomal degradation of ND10 component SP100 by herpesvirus saimiri critically depends on lysine 819 of the viral FGARAT homolog ORF3
Florian Full (Erlangen/Germany), Alexander  Hahn, Anna  Großkopf (Göttingen/Germany), Brigitte  Scholz, Doris Jungnickl, Armin Ensser* (Erlangen/Germany)
09:30  TRIM43 restricts KSHV reactivation by regulating centrosome integrity
Florian Full* (Erlangen/Germany; Chicago, IL/USA), Michiel van Gent, Konstantin Sparrer (Chicago, IL/USA), Stephanie Walter, Myriam Scherer, Michael  Stürzl1, Thomas Stamminger, Armin Ensser (Erlangen/Germany, Michaela Gack (Chicago, IL/USA)
09:45  KSHV ORF20 interacts with the oligoadenylate synthetase-like protein (OASL)
Kendra A. Bussey*, Lisa Osbelt, Ulrike Lau, Christine Steffens, Josef Wissing, Lothar Jänsch (Braunschweig/Germany), Hans Henrik Gad, Rune Hartmann (Aarhus/Denmark), Melanie M. Brinkmann (Braunschweig/Germany)
10:00  KSHV regulation of the MicroRNA biogenesis pathway
Insun Kook, Christine Happel, Joseph Ziegelbauer* (Bethesda, MD/USA)
10:15 – 10:45 Coffee break
10:45 – 12:45 Session 6: Lytic Replication
Chairs Ethel Cesarman (New York, NY/USA), Dean Kedes (Charlottesville, VA/USA)
10:45  Proteomic analysis of human endothelial cells to study KSHV reactivation
Ildar I. Gabaev*, James C Williamson (Cambridge/UK), Thomas F Schulz (Hannover/Germany), Paul J Lehner (Cambridge/UK)
11:00  Nucleolar stress enhances lytic reactivation of the Kaposi's sarcoma-associated herpesvirus Anastasia
Anastasia Gelgor, Chen Gam ze Letova, Yana Yegorov, Nofar Nahum, Inna Kalt, Ronit Sarid*  (Ramat Gan/Israel)
11:15 HHV-8 vIRF-1 regulates mitochondrial content during lytic replication
Yong Bong Choi (Baltimore, MD/USA)
11:30 A short ORF45 peptide inhibits lytic replication of Kaposi's sarcoma- associated herpesvirus
Xiaojuan Li, Lu Huang, Ersheng Kuang (Guangzhou/China)
11:45  Absence of vFGARAT member ORF75A reduces the specific infectivity of MHV68 particles and impairs acute replication and reactivation from latency in the host
Nana  Minkah, Nick Van Skike, Gary Wu, Peter Benziger (Stony Brook, NY/USA), Mehmet Kara, Scott Tibbetts (Gainsville, FL/USA), Deborah  Kim-Holzapfel, Jarrod French (Stony Brook, NY/USA), Darby Oldenburg, Douglas White (La Crosse, WI/USA), Laurie Krug* (Stony Brook, NY/USA)
12:00  Mutational analysis of viral uracil DNA glycosylase reveals enzymatic and non-enzymatic roles, independent of host UNG, in gammaherpesvirus pathogenesis
Qiwen Dong, Orchi Anannya, William Schutt (Stony Brook, NY/USA), Darby Oldenburg (La Crosse, WI/USA), James Forrest (Little Rock, AR/USA), Douglas White (La Crosse, WI/USA), Yunxiang Mu4, Kevin McBride (Smithville, TX/USA), Laurie Krug* (Stony Brook, NY/USA)
12:15  MiR-627-5p and MiR-711 mediate HIV-1 Vpr inhibition of Kaposi's sarcoma-associated herpesvirus lytic replication by inactivating notch signaling
Qin Yan*, Wan Li, Chenyou Shen, Runran Zhao, Fei Wang (Nanjing/China), Shou-Jiang Gao (Los Angeles, CA/USA), Chun  Lu (Nanjing/China)
12:30 Identification and characterization of RNF213 as an interferon-stimulated gene product that inhibits gammaherpesvirus infection through targeting RTA

Huabin Tian, Kuai Yu, Liang He, Hongtao Xu, Chuanhui Han, Liguo Zhang, Guangxia Gao, Hongyu Deng* (Beijing/China)
12:45 – 13:30 Lunch break
13:30 – 15:00 Poster Session II
15:00 – 16:00 Session 7: Viral Pathogenesis and Animal Model
Chairs Scott Wong (Beaverton, OR/USA), Charles Wood (Lincoln, NE/USA)
15:00  Analyzing mechanisms of KSHV latency and intervention using novel in vitro and in vivo models
Tatyana Dubich*, Christoph  Lipps, Milada Butueva, Tobias May, Marc Stadler (Braunschweig/Germany), Thomas  Schulz (Hannover/Germany), Dagmar  Wirth (Braunschweig/Germany)
15:15  Establishment and application of Primary effusion lymphoma mice model
Seiji Okada*, Ryusho Kariya, Hiroki Goto (Kumamoto/Japan)
15:30  Evidences for Kaposi's sarcoma originating from oral mesenchymal stem cells through KSHV-induced mesenchymal-to- endothelial transition
Yuqing Li, Canrong Zhong, Yan Wang (Guangzhou, China), Yan Yuan* (Philadelphia, PA/USA)
15:45  The endosomal Toll-like receptors act in concert to detect MHV68 infection
Kendra A. Bussey*, Sripriya Murthy, Baca Chan, Elisa Reimer (Braunschweig/Germany), Heiko Adler (München/Germany), Melanie M. Brinkmann (Braunschweig/Germany)
16:00 – 16:30 Coffee break
16:30 – 18:30 Session 8: Virus-Host Interaction III
Chairs Laurie Krug (Stony Brook, NY/USA), Michael Lagunoff (Seattle, WA/USA)
16:30  Antiviral activity of a cellular glutamine amidotranferase reveals a key role of protein deamidation in regulating protein cytoplasm to nucleus transport
Junhua Li, Jun Xiao, Jun Zhao, Junjie  Zhang, Yi Zeng, Pinghui Feng* (Los Angeles, CA/USA)
16:45  A critical role of glutamine gamma-nitrogen for nucleotide biosynthesis in cancer cells hijacked by an oncogenic virus Ying Zhu, Tingting Li, Suzane  Ramos da Silva, Jae-Jin Lee (Nanjing/China), Chun Lu (Los Angeles, CA/USA), Hyungjin  Eoh, Jae U.  Jung (Nanjing/China), Shou Jiang Gao* (Los Angeles, CA/USA)
17:00  KSHV manipulation of the host iron regulon
Jean Gustin*, Ying Bai, Ashlee Moses (Beaverton, OR/USA)
17:15  KSHV latent to lytic switch in PEL cells modulates host transcriptome profile
Vladimir Majerciak*, Caitlin  Shi (Frederick, MD/USA), Wenjing  Yang (Bethesda, MD/USA), Ting Ni (Shanghai/China), Jun Zhu (Bethesda, MD/USA), Zhi-Ming Zheng(Frederick, MD/USA)
17:30  The impact of eukaryotic DExD/H box helicases DDX24, DHX29, and DDX49 on lytic replication of kaposi's sarcoma associated herpesvirus
Jacquelyn Serfecz, Masmudur Rahman, Grant McFaden, Rolf Renne* (Gainesville, FL/USA)
17:45  A conserved eph family receptor-binding motif and novel receptor interactions of the gH/gL complex of KSHV and RRV – determinants of infectivity and tropism
Anna K. Grosskopf* (Göttingen/Germany), Armin Ensser (Erlangen/Germany), Sarah Schlagowski (Göttingen/Germany), Ronald C. Desrosiers (Miami, FL/USA), Alexander S. Hahn (Göttingen/Germany)
18:00  The Ephrin A2 receptor tyrosin kinase (EphA2) is downregulated by the KSHV immediate-early transactivator RTA
Jonas Lanfer, Marvin Fischer, Alina Disch, Angela Holzer, Frank Neipel* (Erlangen/Germany)
18:15  KSHV specific CD4+ and CD8+ T cell clones reveal effector phenotype that is transferrable to autologous T cells
Mathew Trivett, Nazzarena Labo*, Romin Roshan, Wendell Miley, Vickie Marshall, Lori Coren, Victor Ayala (Frederick, MD/USA), Rodrigo Matus-Nicodemos (Bethesda, MD/USA), Christine Fennessey (Frederick, MD/USA), Daniel  Douek (Bethesda, MD/USA), Brandon Keele, Jeffrey Lifson, Claes Ohlen, David Ott, Denise Whitby (Frederick, MD/USA)
19:00 – 23:00 BANQUET dinner
08:30 – 09:30 Session 9: Assembly & Structure
Chairs Hongyu Deng (Beijing/China), Eva Gottwein (Chicago, IL/USA)
08:30  Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins
Joanna Sztuba-Solinska*, Jason Rausch, Rodman Smith, Jennifer Miller, Denise Whitby, Stuart Le Grice (Frederick, MD/USA)
08:45  The molecular basis of transcript processing by the KSHV virus/The molecular basis underlying KSHV-SOX mediated host shut off
Hyunah Lee*, Tracey Barrett (London/UK)
09:00  Structural and functional study of KSHV ORF57 protein
Fei Yuan (Shanghai/China)
09:15  Viral Bcl2 for KSHV virion assembly
Jae Jung*, Qiming Liang (Glendale, CA/USA)
09:30  Structural and biochemical analysis of LANA interactions with USP7:
Incorporation of a glutamine residue in substrate competition by KSHV LANA
Rajesh Ponnusamy (Brighton/UK), Tania F. Custodio (Aarhus/DK), Rute M. 
Chitas, Colin E. McVey* (Oeiras/PT)
09:45 – 10:15 Coffee break
10:15 – 11:45 Session 10: Novel Therapeutic Targets/Therapies
Chairs Jae Jung (Los Angeles, CA/USA), Ke Lan (Wuhan/China)
10:15  Combined inhibition of AKT and mTOR is effective against primary effusion lymphoma
Ricardo Rivera-Soto*, Penny Anders (Chapel Hill, NC/USA), Yi Yu, Ronald Savage, Brian Schwartz (Burlington, MA/USA), Dirk Dittmer, Blossom  Damania (Chapel Hill, NC/USA)
10:30  Targeting the mtor pathway as therapy for primary effusion lymphoma
Carolina Caro-Vegas*, Hyowon An, Charlene Santos, Hong Yuan, Dirk Dittmer (Chapel Hill, NC/USA)
10:45  Hyperglobulinemia in KSHV latency mice is prevented by everolimus
Sang-Hoon Sin, Anthony Eason (Chapel Hill, NC/USA), Yongbaek Kim (Seoul/South Korea), SunAh Kang, Hyowon An, Dirk Dittmer (Chapel Hill, NC/USA)
11:00  Inhibition of the PLCγ1 recruitment to the Kaposi's sarcoma- associated herpesvirus K15 protein as a novel approach to interfere with early viral lytic gene expression and pathogenesis?
Naira Samarina*, Bizunesh  Abere, Jessica  Rückert, Guillaume  Beauclair, Eleonora  Naimo (Hannover/Germany; Braunschweig/Germany), Thomas  Krey (Hannover/Germany), Sandra  Koch, Thomas F.  Schulz (Hannover/Germany; Braunschweig/Germany)
11:15  Targeting vFLIP for the treatment of KSHV-associated diseases: Losing NEMO interaction
Jouliana Sadek* (New York, NY/USA), Arthur Hauenstein (Boston, MA/USA), Hao Wu, Michel Cuendet, Harel Weinstein, Fraser Glickman, Ethel Cesarman (New York, NY/USA)
11:30 Developing a "kick-and-kill" strategy for KSHV
Stuart Le Grice*, Fardokht  Abulwerdi, Regan LeBlanc, Jennifer Miller, Takashi Masaoka, Jason Rausch (Frederick, MD/USA), Tom Kenderdine (Albany, NY/USA), Owen Becette, Theodore Dayie (College Park, MD/USA), Elena Cornejo-Castro (College Park, MD/USA; Frederick, MD/USA), Denise Whitby Frederick, MD/USA), Daniel Fabris (College Park, MD/USA), Joanna Sztuba-Solinska (Frederick, MD/USA)
11:45 – 12:15 Closing and next year outlook
12:15 End of Workshop